📚 Series

Generative Biology: The Flywheel of AI-Driven Drug Discovery

How AI is solving the protein folding problem and enabling rational design of therapeutics.

7Parts

77 minTotal Read Time

AdvancedLevel

Start Reading Part 1

Parts

Min Read

77 min

Complexity

Advanced

Published

Oct 2024

Complete Series Progress

7 parts • Hover to view individual progress

★Key Takeaways

✓Understand the language of life: DNA, RNA, proteins, and biological information

✓Grasp the protein folding problem and AlphaFold's solution

✓Learn inverse folding: designing proteins from first principles

✓Explore small-molecule design and drug discovery acceleration

✓Understand antibody engineering and therapeutic design

✓See the flywheel: how AI drug discovery creates better therapeutics

About This Series

Biology is becoming programmable. This 7-part series explores how generative AI is solving the protein folding problem (AlphaFold), enabling inverse folding (designing proteins with specified functions), and accelerating drug discovery through small-molecule design, antibody engineering, and virtual labs. Discover the flywheel effect where AI-designed therapeutics power a feedback loop of continuous improvement.

All Parts

Part 1

14%

The Language of Life (Part 1): How Generative AI Learned to Speak 'Protein'

From linguistics to biophysics—understanding how Protein Language Models learn the deep grammar of biology from 200M+ sequences.

5 Min. Read

Part 2

29%

The Language of Life (Part 2): Beyond AlphaFold—From 'Reading' a Fold to 'Writing' a Function

Solving the inverse folding problem with 3D diffusion models to design novel protein functions from first principles.

5 Min. Read

Part 3

43%

The Language of Life (Part 3): The 'Digital Locksmith'—Generative AI for Small Molecule Design

Moving beyond brute-force HTS to intelligent, 3D-equivariant generation of optimized small molecule drugs.

3 Min. Read

Part 4

57%

The Language of Life (Part 4): 'Dreaming Up' Antibodies—Generative AI for Biologics

Co-generating binding and developability with multi-objective antibody design platforms.

3 Min. Read

Part 5

71%

The Language of Life (Part 5): The 'Virtual Lab'—How We Validate Generative Drugs In Silico

Testing 1,000 drug candidates in one day using Digital Twin systems biology simulations and proteome-wide toxicity screening.

3 Min. Read

Part 6

86%

The Language of Life (Part 6): Closing the Loop—From In Silico Design to In Vitro Data

The self-driving laboratory flywheel that connects AI theory to experimental facts through active learning.

3 Min. Read

Part 7

100%

The Language of Life (Part 7): Generative Biology is Here—How to Start Your First In Silico Design Program

Partner with the platform: Two tangible first projects to accelerate your R&D pipeline today.

3 Min. Read